› 2x57

X-ray diffraction
2.1Å resolution

Crystal structure of the extracellular domain of human Vasoactive intestinal polypeptide receptor 2

Released:
DOI: 10.2210/pdb2x57/pdb
PDB entry 2x57 coloured by chain, front view.
PDB entry 2x57 coloured by chain, side view.
PDB entry 2x57 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pike ACW, Barr AJ, Quigley A, Burgess Brown N, de Riso A, Bullock A, Berridge G, Muniz JRC, Chaikaud A, Vollmar M, Krojer T, Ugochukwu E, von Delft F, Edwards A, Arrowsmith CH, Weigelt J, Bountra C, Carpenter EP

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo hexamer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vasoactive intestinal polypeptide receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 116 amino acids
Theoretical weight: 13.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41587 (Residues: 26-118; Coverage: 22%)
Gene names: VIP2R, VIPR2
Sequence domains: Hormone receptor domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 99.7Å b: 99.7Å c: 104.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.235
Expression system: Escherichia coli BL21(DE3)

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