› 2x5y

X-ray diffraction
1.05Å resolution

Human ZC3HAV1 (ARTD13), C-terminal domain

Released:
DOI: 10.2210/pdb2x5y/pdb
PDB entry 2x5y coloured by chain, front view.
PDB entry 2x5y coloured by chain, side view.
PDB entry 2x5y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg T, Klepsch M, Thorsell AG, Andersson CD, Linusson A, Schüler H
J Biol Chem 290 7336-44 (2015)
PMID: 25635049

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger CCCH-type antiviral protein 1 Chain: A
Molecule details ›
Chain: A
Length: 173 amino acids
Theoretical weight: 20.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7Z2W4 (Residues: 724-896; Coverage: 19%)
Gene names: PRO1677, ZC3HAV1, ZC3HDC2
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Structure domains: Phosphoenolpyruvate Carboxykinase; domain 3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 47.858Å b: 54.103Å c: 69.284Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.131 0.13 0.149
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

Translation inhibition and stress granules in the antiviral immune response.
McCormick et al. (2017)
19 more

11 mentions without citation

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.
Karlberg et al. (2013)
10 more