› 2x7f

X-ray diffraction
2.8Å resolution

Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1 inhibitor

Released:
DOI: 10.2210/pdb2x7f/pdb
PDB entry 2x7f coloured by chain, front view.
PDB entry 2x7f coloured by chain, side view.
PDB entry 2x7f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vollmar M, Alfano I, Shrestha B, Bray J, Muniz JRC, Roos A, Filippakopoulos P, Burgess-Brown N, Ugochukwu E, Gileadi O, Phillips C, Mahajan P, Pike ACW, Fedorov O, Chaikuad A, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193843 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TRAF2 and NCK-interacting protein kinase Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 326 amino acids
Theoretical weight: 37.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UKE5 (Residues: 1-325; Coverage: 24%)
Gene names: KIAA0551, TNIK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 824 5 x 824
Ligand NA 5 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 52.972Å b: 79.074Å c: 214.159Å
α: 90° β: 91.87° γ: 90°
R-values:
R R work R free
0.21 0.209 0.229
Expression system: Spodoptera frugiperda

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