› 2xhs

X-ray diffraction
2.8Å resolution

Crystal structure of the ligand binding domain of Fushi tarazu factor 1 of Drosophila melanogaster.

Released:
DOI: 10.2210/pdb2xhs/pdb
PDB entry 2xhs coloured by chain, front view.
PDB entry 2xhs coloured by chain, side view.
PDB entry 2xhs coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of Fushi tarazu factor 1 ligand binding domain/Fushi tarazu peptide complex identifies new class of nuclear receptors.
Yoo J, Ko S, Kim H, Sampson H, Yun JH, Choe KM, Chang I, Arrowsmith CH, Krause HM, Cho HS, Lee W
J Biol Chem 286 31225-31 (2011)
PMID: 21775434

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136263 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear hormone receptor FTZ-F1 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.8 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: P33244 (Residues: 790-1027; Coverage: 23%)
Gene names: CG4059, NR5A3, ftz-f1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Segmentation protein fushi tarazu Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 989 Da
Source organism: Drosophila melanogaster
Expression system: Not provided
UniProt:
  • Canonical: P02835 (Residues: 107-115; Coverage: 2%)
Gene names: CG2047, ftz

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P3121
Unit cell:
a: 97.931Å b: 97.931Å c: 123.466Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.246
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

The juvenile hormone signaling pathway in insect development.
Jindra et al. (2013)
2 more

5 mentions without citation

The Drosophila juvenile hormone receptor candidates methoprene-tolerant (MET) and germ cell-expressed (GCE) utilize a conserved LIXXL motif to bind the FTZ-F1 nuclear receptor.
Bernardo et al. (2012)
4 more