Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Protease NS2 (preferred)
PDBe Complex ID:
PDB-CPX-151107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-directed RNA polymerase
Molecule details ›
Chains: A, B, C
Length: 576 amino acids
Theoretical weight: 63.79 KDa
Source organism: Hepatitis C virus (isolate H77)
Expression system: Escherichia coli BL21(DE3)
UniProt:
Structure domains: Alpha-Beta Plaits
Length: 576 amino acids
Theoretical weight: 63.79 KDa
Source organism: Hepatitis C virus (isolate H77)
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P27958 (Residues: 2421-2990; Coverage: 19%)
Structure domains: Alpha-Beta Plaits
