› 2xkx

Hybrid

Single particle analysis of PSD-95 in negative stain

Released:
DOI: 10.2210/pdb2xkx/pdb
PDB entry 2xkx coloured by chain, front view.
PDB entry 2xkx coloured by chain, side view.
PDB entry 2xkx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Self-directed assembly and clustering of the cytoplasmic domains of inwardly rectifying Kir2.1 potassium channels on association with PSD-95.
Fomina S, Howard TD, Sleator OK, Golovanova M, O'Ryan L, Leyland ML, Grossmann JG, Collins RF, Prince SM
Biochim Biophys Acta 1808 2374-89 (2011)
PMID: 21756874
Related structures: EMD-1761

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151890 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 721 amino acids
Theoretical weight: 80.2 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P31016 (Residues: 1-724; Coverage: 100%)
Gene names: Dlg4, Dlgh4, Psd95
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Experimental Method: X-ray solution scattering, Electron Microscopy
Resolution: 22.9Å
Relevant EMDB volumes: EMD-1761
Expression system: Escherichia coli BL21

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Citations

8 citation in other articles

Supertertiary structure of the synaptic MAGuK scaffold proteins is conserved.
McCann et al. (2012)
7 more