2xpx

X-ray diffraction
2.05Å resolution

Crystal structure of BHRF1:Bak BH3 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-136631 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator BHRF1 Chain: A
Molecule details ›
Chain: A
Length: 173 amino acids
Theoretical weight: 19.85 KDa
Source organism: human gammaherpesvirus 4
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03182 (Residues: 1-160; Coverage: 84%)
Gene name: BHRF1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2 homologous antagonist/killer Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 2.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16611 (Residues: 67-92; Coverage: 12%)
Gene names: BAK, BAK1, BCL2L7, CDN1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 62.387Å b: 62.387Å c: 93.729Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.184 0.217
Expression system: Escherichia coli BL21(DE3)