› 2xte

X-ray diffraction
3.9Å resolution

Structure of the TBL1 tetramerisation domain

Released:
DOI: 10.2210/pdb2xte/pdb
PDB entry 2xte coloured by chain, front view.
PDB entry 2xte coloured by chain, side view.
PDB entry 2xte coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW
Nat Struct Mol Biol 18 177-84 (2011)
PMID: 21240272

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
F-box-like/WD repeat-containing protein TBL1X Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 90 amino acids
Theoretical weight: 9.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60907 (Residues: 52-141; Coverage: 16%)
Gene names: TBL1, TBL1X
Sequence domains: LisH
Structure domains: Mitochondrial Import Receptor Subunit Tom20; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 88.02Å b: 150.19Å c: 164.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.273 0.302
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

29 review citations

Medulloblastomics: the end of the beginning.
Northcott et al. (2012)
28 more

2 mentions without citation

Distinct biochemical properties of the class I histone deacetylase complexes.
Lee et al. (2022)
1 more