› 2xvt

X-ray diffraction
2.05Å resolution

Structure of the extracellular domain of human RAMP2

Released:
DOI: 10.2210/pdb2xvt/pdb
PDB entry 2xvt coloured by chain, front view.
PDB entry 2xvt coloured by chain, side view.
PDB entry 2xvt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Quigley A, Pike ACW, Burgess-Brown N, Krojer T, Shrestha L, Goubin S, Kim J, Das S, Muniz JRC, Canning P, Chaikuad A, Vollmar M, von Delft F, Arrowsmith CH, Weigelt J, Edwards AM, Bountra C, Barr AJ, Carpenter EP

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo trimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor activity-modifying protein 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 94 amino acids
Theoretical weight: 10.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60895 (Residues: 48-139; Coverage: 69%)
Gene name: RAMP2
Sequence domains: Receptor activity modifying family
Structure domains: Receptor activity modifying family

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02, DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 59.759Å b: 90.984Å c: 92.056Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.246
Expression system: Escherichia coli BL21(DE3)

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