Function and Biology Details
Reactions catalysed:
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to yield C5a and C5b.
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133225 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
Complement C3 beta chain
Molecule details ›
Chains: A, C
Length: 642 amino acids
Theoretical weight: 71.15 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 642 amino acids
Theoretical weight: 71.15 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P01024 (Residues: 23-664; Coverage: 39%)
Sequence domains:
- Macroglobulin domain MG1
- MG2 domain
- Macroglobulin domain MG3
- Macroglobulin domain MG4
- Alpha-2-macroglobulin bait region domain
Complement C3b alpha' chain
Molecule details ›
Chains: B, D
Length: 912 amino acids
Theoretical weight: 103.76 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 912 amino acids
Theoretical weight: 103.76 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 752-1663; Coverage: 56%)
Sequence domains:
- Alpha-2-macroglobulin family
- Complement component 3, CUB domain 1
- A-macroglobulin TED domain
- Complement component 3, CUB domain 2
- A-macroglobulin receptor binding domain
- UNC-6/NTR/C345C module
Complement factor B
Molecule details ›
Chains: F, H
Length: 732 amino acids
Theoretical weight: 82.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 732 amino acids
Theoretical weight: 82.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P00751 (Residues: 35-764; Coverage: 99%)
Sequence domains:
Structure domains:
Complement factor D
Molecule details ›
Chains: I, J
Length: 228 amino acids
Theoretical weight: 24.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 228 amino acids
Theoretical weight: 24.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P00746 (Residues: 26-253; Coverage: 98%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
