Function and Biology Details
Reaction catalysed:
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to yield C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133304 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C3 beta chain
Molecule details ›
Chains: A, C, E, G
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P01024 (Residues: 23-667; Coverage: 39%)
Sequence domains:
- Macroglobulin domain MG1
- MG2 domain
- Macroglobulin domain MG3
- Macroglobulin domain MG4
- Alpha-2-macroglobulin bait region domain
Complement C3b alpha' chain
Molecule details ›
Chains: B, D, F, H
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Sequence domains:
- Alpha-2-macroglobulin family
- Complement component 3, CUB domain 1
- A-macroglobulin TED domain
- Complement component 3, CUB domain 2
- A-macroglobulin receptor binding domain
- UNC-6/NTR/C345C module
Complement factor B
Molecule details ›
Chains: I, J, K, L
Length: 741 amino acids
Theoretical weight: 83.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 741 amino acids
Theoretical weight: 83.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P00751 (Residues: 26-764; Coverage: 100%)
Sequence domains:
Structure domains:
