› 2y1y

X-ray diffraction
2Å resolution

Human alphaB crystallin ACD(residues 71-157)

Released:
DOI: 10.2210/pdb2y1y/pdb
PDB entry 2y1y coloured by chain, front view.
PDB entry 2y1y coloured by chain, side view.
PDB entry 2y1y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove.
Clark AR, Naylor CE, Bagnéris C, Keep NH, Slingsby C
J Mol Biol 408 118-34 (2011)
PMID: 21329698

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02511 (Residues: 71-157; Coverage: 50%)
Gene names: CRYA2, CRYAB, HSPB5
Sequence domains: Hsp20/alpha crystallin family
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand MRD 1 x MRD
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P4322
Unit cell:
a: 36.03Å b: 36.03Å c: 148.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
Haslbeck et al. (2015)
19 more

8 mentions without citation

Mechanisms of Small Heat Shock Proteins.
Janowska et al. (2019)
7 more