› 2y5l

X-ray diffraction
2.2Å resolution

orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase

Released:
DOI: 10.2210/pdb2y5l/pdb
PDB entry 2y5l coloured by chain, front view.
PDB entry 2y5l coloured by chain, side view.
PDB entry 2y5l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E
Bioorg Med Chem Lett 21 3237-42 (2011)
PMID: 21550236

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-1,6-bisphosphatase 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 338 amino acids
Theoretical weight: 36.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09467 (Residues: 1-338; Coverage: 100%)
Gene names: FBP, FBP1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RO8 8 x RO8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 66.791Å b: 285.084Å c: 83.687Å
α: 90° β: 97.3° γ: 90°
R-values:
R R work R free
0.207 0.205 0.254
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis.
Jitrapakdee S. (2012)
1 more