› 2y9t

Solution NMR

Structural basis of p63a SAM domain mutants involved in AEC syndrome

Released:
DOI: 10.2210/pdb2y9t/pdb
PDB entry 2y9t coloured by chain, ensemble of 20 models, front view.
PDB entry 2y9t coloured by chain, ensemble of 20 models, side view.
PDB entry 2y9t coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of p63α SAM domain mutants involved in AEC syndrome.
Sathyamurthy A, Freund SM, Johnson CM, Allen MD, Bycroft M
FEBS J 278 2680-8 (2011)
PMID: 21615690

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein 63 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H3D4 (Residues: 543-622; Coverage: 12%)
Gene names: KET, P63, P73H, P73L, TP63, TP73L
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.
Uversky et al. (2014)
1 more

2 mentions without citation

Structural diversity of p63 and p73 isoforms.
Osterburg et al. (2022)
1 more