› 2y9u

X-ray diffraction
1.6Å resolution

Structural basis of p63a SAM domain mutants involved in AEC syndrome

Released:
DOI: 10.2210/pdb2y9u/pdb
PDB entry 2y9u coloured by chain, front view.
PDB entry 2y9u coloured by chain, side view.
PDB entry 2y9u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of p63α SAM domain mutants involved in AEC syndrome.
Sathyamurthy A, Freund SM, Johnson CM, Allen MD, Bycroft M
FEBS J 278 2680-8 (2011)
PMID: 21615690

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein 63 Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 7.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H3D4 (Residues: 545-611; Coverage: 10%)
Gene names: KET, P63, P73H, P73L, TP63, TP73L
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 34.624Å b: 38.309Å c: 44.516Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.206
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.
Uversky et al. (2014)
2 more

4 mentions without citation

Intrinsically disordered regions of p53 family are highly diversified in evolution.
Xue et al. (2013)
3 more