› 2ydv

X-ray diffraction
2.6Å resolution

Thermostabilised HUMAN A2a Receptor with NECA bound

Released:
DOI: 10.2210/pdb2ydv/pdb
PDB entry 2ydv coloured by chain, front view.
PDB entry 2ydv coloured by chain, side view.
PDB entry 2ydv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.
Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG
Nature 474 521-5 (2011)
PMID: 21593763

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.02 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P29274 (Residues: 1-317; Coverage: 77%)
Gene names: ADORA2, ADORA2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

2 bound ligands:
Ligand NEC 1 x NEC
Ligand SOG 5 x SOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 76.936Å b: 99.551Å c: 79.655Å
α: 90° β: 93.31° γ: 90°
R-values:
R R work R free
0.234 0.233 0.258
Expression system: Trichoplusia ni

Quick links

Citations

103 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
102 more

126 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
125 more