› 2yf0

X-ray diffraction
2.65Å resolution

Human Myotubularin related protein 6 (MTMR6)

Released:
DOI: 10.2210/pdb2yf0/pdb
PDB entry 2yf0 coloured by chain, front view.
PDB entry 2yf0 coloured by chain, side view.
PDB entry 2yf0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Moche M, Tresaugues L, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson I, Karlberg T, Kotenyova T, Kouznetsova E, Nyman T, Persson C, Schuler H, Schutz P, Siponen MI, Thorsell AG, VanDenBerg S, Wahlberg E, Weigelt J, Welin M, Nordlund P

Function and Biology Details

Reactions catalysed: 
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myotubularin-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 512 amino acids
Theoretical weight: 59.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y217 (Residues: 1-507; Coverage: 82%)
Gene name: MTMR6
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6422
Unit cell:
a: 85.735Å b: 85.735Å c: 448.446Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.259 0.258 0.288
Expression system: Escherichia coli BL21(DE3)

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