› 2ygd

Electron Microscopy
9.4Å resolution

Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach

Released:
DOI: 10.2210/pdb2ygd/pdb
PDB entry 2ygd coloured by chain, front view.
PDB entry 2ygd coloured by chain, side view.
PDB entry 2ygd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach.
Braun N, Zacharias M, Peschek J, Kastenmüller A, Zou J, Hanzlik M, Haslbeck M, Rappsilber J, Buchner J, Weinkauf S
Proc Natl Acad Sci U S A 108 20491-6 (2011)
PMID: 22143763
Related structures: EMD-1894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 175 amino acids
Theoretical weight: 20.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02511 (Residues: 1-175; Coverage: 100%)
Gene names: CRYA2, CRYAB, HSPB5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9.4Å
Relevant EMDB volumes: EMD-1894
Expression system: Escherichia coli

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Citations

14 review citations

A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
Haslbeck et al. (2015)
13 more

28 mentions without citation

One size does not fit all: the oligomeric states of αB crystallin.
Delbecq et al. (2013)
27 more