› 2ygn

X-ray diffraction
1.85Å resolution

WIF domain of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine

Released:
DOI: 10.2210/pdb2ygn/pdb
PDB entry 2ygn coloured by chain, front view.
PDB entry 2ygn coloured by chain, side view.
PDB entry 2ygn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.
Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY
Nat Struct Mol Biol 18 886-93 (2011)
PMID: 21743455

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195289 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wnt inhibitory factor 1 Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5W5 (Residues: 35-178; Coverage: 41%)
Gene names: UNQ191/PRO217, WIF1
Sequence domains: WIF domain
Structure domains: Wnt, WIF domain

Ligands and Environments

3 bound ligands:
Ligand PCF 1 x PCF
Ligand NAG 1 x NAG
Ligand ACT 1 x ACT
1 modified residue:
Ligand MLY 6 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C222
Unit cell:
a: 49.912Å b: 134.138Å c: 60.378Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.224
Expression system: Homo sapiens

Quick links

Citations

28 review citations

Update on Wnt signaling in bone cell biology and bone disease.
Monroe et al. (2012)
27 more

4 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
3 more