› 2ygp

X-ray diffraction
2.22Å resolution

WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine

Released:
DOI: 10.2210/pdb2ygp/pdb
PDB entry 2ygp coloured by chain, front view.
PDB entry 2ygp coloured by chain, side view.
PDB entry 2ygp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.
Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY
Nat Struct Mol Biol 18 886-93 (2011)
PMID: 21743455

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195289 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wnt inhibitory factor 1 Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 21.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5W5 (Residues: 35-210; Coverage: 50%)
Gene names: UNQ191/PRO217, WIF1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand PCF 1 x PCF
Ligand NAG 1 x NAG
Ligand CA 1 x CA
Ligand SPD 1 x SPD
1 modified residue:
Ligand MLY 6 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C222
Unit cell:
a: 50.76Å b: 134.241Å c: 60.193Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.229
Expression system: Homo sapiens

Quick links

Citations

28 review citations

Update on Wnt signaling in bone cell biology and bone disease.
Monroe et al. (2012)
27 more

1 mention without citation

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.
Malinauskas et al. (2011)