› 2ykg

X-ray diffraction
2.5Å resolution

Structural insights into RNA recognition by RIG-I

Released:
DOI: 10.2210/pdb2ykg/pdb
PDB entry 2ykg coloured by chain, front view.
PDB entry 2ykg coloured by chain, side view.
PDB entry 2ykg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into RNA recognition by RIG-I.
Luo D, Ding SC, Vela A, Kohlway A, Lindenbach BD, Pyle AM
Cell 147 409-22 (2011)
PMID: 22000018

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132020 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Antiviral innate immune response receptor RIG-I Chain: A
Molecule details ›
Chain: A
Length: 696 amino acids
Theoretical weight: 79.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95786 (Residues: 230-925; Coverage: 75%)
Gene names: DDX58, RIGI
Sequence domains:
Structure domains:
5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 nucleotides
Theoretical weight: 3.21 KDa
Source organism: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 47.618Å b: 76.208Å c: 219.825Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.273

Quick links

Citations

92 review citations

Innate immune sensing and signaling of cytosolic nucleic acids.
Wu et al. (2014)
91 more

22 mentions without citation

A structure-based model of RIG-I activation.
Kolakofsky et al. (2012)
21 more