2yq6

X-ray diffraction
1.8Å resolution

Structure of Bcl-xL bound to BimSAHB

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-128973 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 2.18 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 147-164; Coverage: 9%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 73.736Å b: 35.336Å c: 61.412Å
α: 90° β: 100.61° γ: 90°
R-values:
R R work R free
0.168 0.166 0.201
Expression systems:
  • Escherichia coli BL21
  • Not provided