› 2yu7

Solution NMR

Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A

Released:
DOI: 10.2210/pdb2yu7/pdb
PDB entry 2yu7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2yu7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2yu7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Kasai T, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150832 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29350 (Residues: 110-214; Coverage: 18%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains: SH2 domain
Structure domains: SH2 domain
NKG2-A/NKG2-B type II integral membrane protein Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P26715 (Residues: 33-47; Coverage: 6%)
Gene names: KLRC1, NKG2A

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, restrainted molecular dynamics
Expression system: Not provided

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