› 2yuk

Solution NMR

Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog

Released:
DOI: 10.2210/pdb2yuk/pdb
PDB entry 2yuk coloured by chain, ensemble of 20 models, front view.
PDB entry 2yuk coloured by chain, ensemble of 20 models, side view.
PDB entry 2yuk coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Abe H, Tochio N, Miyamoto K, Koshiba S, Harada T, Watanabe S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase 2C Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8NEZ4 (Residues: 1631-1713; Coverage: 2%)
Gene names: HALR, KIAA1506, KMT2C, MLL3
Structure domains: High mobility group box domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links