› 2yv6

X-ray diffraction
2.5Å resolution

Crystal structure of human Bcl-2 family protein Bak

Released:
DOI: 10.2210/pdb2yv6/pdb
PDB entry 2yv6 coloured by chain, front view.
PDB entry 2yv6 coloured by chain, side view.
PDB entry 2yv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
Wang H, Takemoto C, Akasaka R, Uchikubo-Kamo T, Kishishita S, Murayama K, Terada T, Chen L, Liu ZJ, Wang BC, Sugano S, Tanaka A, Inoue M, Kigawa T, Shirouzu M, Yokoyama S
J Struct Biol 166 32-7 (2009)
PMID: 19135534

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2 homologous antagonist/killer Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.64 KDa
Source organism: Homo sapiens
Expression system: Cell-free protein synthesis
UniProt:
  • Canonical: Q16611 (Residues: 23-185; Coverage: 77%)
Gene names: BAK, BAK1, BCL2L7, CDN1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6522
Unit cell:
a: 61.824Å b: 61.824Å c: 137.482Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.214 0.248
Expression system: Cell-free protein synthesis

Quick links

Citations

8 review citations

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy.
Ralph et al. (2010)
7 more

10 mentions without citation

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.
Luna-Vargas et al. (2016)
9 more