2z3r

X-ray diffraction
2Å resolution

Crystal structure of the IL-15/IL-15Ra complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-154210 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-15 Chains: A, C, E, G, I, K, M, O
Molecule details ›
Chains: A, C, E, G, I, K, M, O
Length: 119 amino acids
Theoretical weight: 13.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40933 (Residues: 49-162; Coverage: 86%)
Gene name: IL15
Sequence domains: Interleukin 15
Structure domains: Interleukin-15/Interleukin-21
Soluble interleukin-15 receptor subunit alpha Chains: B, D, F, H, J, L, N, P
Molecule details ›
Chains: B, D, F, H, J, L, N, P
Length: 107 amino acids
Theoretical weight: 11.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13261 (Residues: 31-132; Coverage: 43%)
Gene name: IL15RA
Structure domains: Rubrerythrin, domain 2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 81.8Å b: 127.035Å c: 191.331Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.25
Expression system: Escherichia coli