› 2z5v

Solution NMR

Solution structure of the TIR domain of human MyD88

Released:
DOI: 10.2210/pdb2z5v/pdb
PDB entry 2z5v coloured by chain, ensemble of 20 models, front view.
PDB entry 2z5v coloured by chain, ensemble of 20 models, side view.
PDB entry 2z5v coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.
Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M
Proc Natl Acad Sci U S A 106 10260-5 (2009)
PMID: 19506249

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid differentiation primary response protein MyD88 Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 17.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99836 (Residues: 148-296; Coverage: 50%)
Gene name: MYD88
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Molecular basis of NF-κB signaling.
Napetschnig et al. (2013)
27 more

24 mentions without citation

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
23 more