› 2z63

X-ray diffraction
2Å resolution

Crystal structure of the TV8 hybrid of human TLR4 and hagfish VLRB.61

Released:
DOI: 10.2210/pdb2z63/pdb
PDB entry 2z63 coloured by chain, front view.
PDB entry 2z63 coloured by chain, side view.
PDB entry 2z63 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.
Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO
Cell 130 906-17 (2007)
PMID: 17803912

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
LRRNT domain-containing protein; Toll-like receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 570 amino acids
Theoretical weight: 64.5 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00206 (Residues: 27-530; Coverage: 62%)
  • Canonical: Q4G1L2 (Residues: 134-199; Coverage: 26%)
Gene names: TLR4, VLRB
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P31
Unit cell:
a: 88.136Å b: 88.136Å c: 92.205Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.25 0.298
Expression system: Spodoptera frugiperda

Quick links

Citations

205 review citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Kawai et al. (2010)
204 more

30 mentions without citation

The structural biology of Toll-like receptors.
Botos et al. (2011)
29 more