› 2zg1

X-ray diffraction
2.7Å resolution

Crystal Structure of Two N-terminal Domains of Siglec-5 in Complex with 6'-Sialyllactose

Released:
DOI: 10.2210/pdb2zg1/pdb
PDB entry 2zg1 coloured by chain, front view.
PDB entry 2zg1 coloured by chain, side view.
PDB entry 2zg1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural implications of Siglec-5-mediated sialoglycan recognition.
Zhuravleva MA, Trandem K, Sun PD
J Mol Biol 375 437-47 (2008)
PMID: 18022638

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialic acid-binding Ig-like lectin 5 Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 24.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15389 (Residues: 20-233; Coverage: 40%)
Gene names: CD33L2, OBBP2, SIGLEC5
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SIA 1 x SIA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 94.044Å b: 94.044Å c: 209.888Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.246 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Siglec-mediated regulation of immune cell function in disease.
Macauley et al. (2014)
11 more

8 mentions without citation

Glycomimetic Peptides as Therapeutic Tools.
Hoober et al. (2023)
7 more