› 2zg2

X-ray diffraction
2.85Å resolution

Crystal Structure of Two N-terminal Domains of Native Siglec-5

Released:
DOI: 10.2210/pdb2zg2/pdb
PDB entry 2zg2 coloured by chain, front view.
PDB entry 2zg2 coloured by chain, side view.
PDB entry 2zg2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural implications of Siglec-5-mediated sialoglycan recognition.
Zhuravleva MA, Trandem K, Sun PD
J Mol Biol 375 437-47 (2008)
PMID: 18022638

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialic acid-binding Ig-like lectin 5 Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15389 (Residues: 20-233; Coverage: 40%)
Gene names: CD33L2, OBBP2, SIGLEC5
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 93.146Å b: 93.146Å c: 205.805Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.248 0.291
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Siglec-mediated regulation of immune cell function in disease.
Macauley et al. (2014)
10 more

13 mentions without citation

Current Status on Therapeutic Molecules Targeting Siglec Receptors.
Lenza et al. (2020)
12 more