› 2zjc

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor, soluble form Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 157 amino acids
Theoretical weight: 17.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: R3
Unit cell:
a: 135.873Å b: 135.873Å c: 58.023Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.201 0.272
Expression system: Escherichia coli

Quick links

Citations

14 review citations

TNF receptor 2 pathway: drug target for autoimmune diseases.
Faustman et al. (2010)
13 more

6 mentions without citation

In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis.
Ge et al. (2020)
5 more