› 2zno

X-ray diffraction
2.4Å resolution

Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703

Released:
DOI: 10.2210/pdb2zno/pdb
PDB entry 2zno coloured by chain, front view.
PDB entry 2zno coloured by chain, side view.
PDB entry 2zno coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.
Oyama T, Toyota K, Waku T, Hirakawa Y, Nagasawa N, Kasuga JI, Hashimoto Y, Miyachi H, Morikawa K
Acta Crystallogr D Biol Crystallogr 65 786-95 (2009)
PMID: 19622862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P37231 (Residues: 223-504; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand S44 2 x S44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: C2
Unit cell:
a: 93.307Å b: 61.604Å c: 118.973Å
α: 90° β: 103.64° γ: 90°
R-values:
R R work R free
0.24 0.24 0.286
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARĪ±.
Tahri-Joutey et al. (2021)
6 more

12 mentions without citation

Development of Molecular Dynamics and Research Progress in the Study of Slag.
Zhou et al. (2023)
11 more