› 2znp

X-ray diffraction
3Å resolution

Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP204

Released:
DOI: 10.2210/pdb2znp/pdb
PDB entry 2znp coloured by chain, front view.
PDB entry 2znp coloured by chain, side view.
PDB entry 2znp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.
Oyama T, Toyota K, Waku T, Hirakawa Y, Nagasawa N, Kasuga JI, Hashimoto Y, Miyachi H, Morikawa K
Acta Crystallogr D Biol Crystallogr 65 786-95 (2009)
PMID: 19622862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169864 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q03181 (Residues: 170-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand B7G 2 x B7G
Ligand K55 2 x K55
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P21
Unit cell:
a: 39.492Å b: 93.149Å c: 96.37Å
α: 90° β: 97.48° γ: 90°
R-values:
R R work R free
0.23 0.23 0.288
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARĪ±.
Tahri-Joutey et al. (2021)
5 more

9 mentions without citation

Activation of PPARĪ“: from computer modelling to biological effects.
Kahremany et al. (2015)
8 more