› 2zns

X-ray diffraction
2Å resolution

Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with glutamate

Released:
DOI: 10.2210/pdb2zns/pdb
PDB entry 2zns coloured by chain, front view.
PDB entry 2zns coloured by chain, side view.
PDB entry 2zns coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.
Unno M, Shinohara M, Takayama K, Tanaka H, Teruya K, Doh-ura K, Sakai R, Sasaki M, Ikeda-Saito M
J Mol Biol 413 667-83 (2011)
PMID: 21893069

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39086 (Residues: 445-559, 682-820; Coverage: 29%)
Gene names: GLUR5, GRIK1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: C2
Unit cell:
a: 119.391Å b: 63.576Å c: 50.147Å
α: 90° β: 106.73° γ: 90°
R-values:
R R work R free
0.195 0.194 0.225
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
1 more

2 mentions without citation

The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel.
Alfieri et al. (2020)
1 more