› 2znt

X-ray diffraction
1.6Å resolution

Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, dysiherbaine

Released:
DOI: 10.2210/pdb2znt/pdb
PDB entry 2znt coloured by chain, front view.
PDB entry 2znt coloured by chain, side view.
PDB entry 2znt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.
Unno M, Shinohara M, Takayama K, Tanaka H, Teruya K, Doh-ura K, Sakai R, Sasaki M, Ikeda-Saito M
J Mol Biol 413 667-83 (2011)
PMID: 21893069

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39086 (Residues: 445-559, 682-820; Coverage: 29%)
Gene names: GLUR5, GRIK1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand DYH 1 x DYH
Ligand BME 5 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: C2
Unit cell:
a: 118.851Å b: 65.137Å c: 50.059Å
α: 90° β: 107.03° γ: 90°
R-values:
R R work R free
0.2 0.199 0.225
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
1 more

1 mention without citation

The Development of Target-Specific Pose Filter Ensembles To Boost Ligand Enrichment for Structure-Based Virtual Screening.
Xia et al. (2017)