› 2zr8

X-ray diffraction
2.2Å resolution

Crystal Structure of Modified Serine Racemase complexed with Serine

Released:
DOI: 10.2210/pdb2zr8/pdb
PDB entry 2zr8 coloured by chain, front view.
PDB entry 2zr8 coloured by chain, side view.
PDB entry 2zr8 coloured by chain, top view.
Source organism: Schizosaccharomyces pombe
Primary publication:
Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe.
Goto M, Yamauchi T, Kamiya N, Miyahara I, Yoshimura T, Mihara H, Kurihara T, Hirotsu K, Esaki N
J Biol Chem 284 25944-52 (2009)
PMID: 19640845

Function and Biology Details

Reactions catalysed: 
(1a) L-serine = 2-aminoprop-2-enoate + H(2)O
(1a) D-serine = 2-aminoprop-2-enoate + H(2)O
L-serine = D-serine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129887 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine racemase Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 35.09 KDa
Source organism: Schizosaccharomyces pombe
Expression system: Escherichia coli
UniProt:
  • Canonical: O59791 (Residues: 1-323; Coverage: 100%)
Gene names: SPCC320.14, SPCC330.15c, sry1
Sequence domains: Pyridoxal-phosphate dependent enzyme
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand PDD 1 x PDD
Ligand SER 1 x SER
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: C2
Unit cell:
a: 59.54Å b: 72.88Å c: 64.81Å
α: 90° β: 101.73° γ: 90°
R-values:
R R work R free
0.171 0.171 0.216
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment.
Balu DT. (2016)
5 more

5 mentions without citation

The Energy Landscape of Human Serine Racemase.
Raboni et al. (2018)
4 more