› 2zv6

X-ray diffraction
2.7Å resolution

Crystal structure of human squamous cell carcinoma antigen 1

Released:
DOI: 10.2210/pdb2zv6/pdb
PDB entry 2zv6 coloured by chain, front view.
PDB entry 2zv6 coloured by chain, side view.
PDB entry 2zv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of SCCA1 and insight about the interaction with JNK1.
Zheng B, Matoba Y, Kumagai T, Katagiri C, Hibino T, Sugiyama M
Biochem Biophys Res Commun 380 143-7 (2009)
PMID: 19166818

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151529 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin B3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 401 amino acids
Theoretical weight: 45.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29508 (Residues: 2-390; Coverage: 100%)
Gene names: SCCA, SCCA1, SERPINB3
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: R3
Unit cell:
a: 263.48Å b: 263.48Å c: 48.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.19 0.27
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

SERPINB3 and B4: From biochemistry to biology.
Sun et al. (2017)
7 other articles

13 mentions without citation

Heparin enhances serpin inhibition of the cysteine protease cathepsin L.
Higgins et al. (2010)
12 more