› 2zvw

X-ray diffraction
2.5Å resolution

Crystal structure of Proliferating cell nuclear antigen 2 and Short peptide from human P21

Released:
DOI: 10.2210/pdb2zvw/pdb
PDB entry 2zvw coloured by chain, front view.
PDB entry 2zvw coloured by chain, side view.
PDB entry 2zvw coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.
Strzalka W, Oyama T, Tori K, Morikawa K
Protein Sci 18 1072-80 (2009)
PMID: 19388052

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153779 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proliferating cell nuclear antigen 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 275 amino acids
Theoretical weight: 30.33 KDa
Source organism: Arabidopsis thaliana
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ZW35 (Residues: 1-255; Coverage: 97%)
Gene names: At2g29570, F16P2.5, PCNA2
Sequence domains:
Structure domains: Proliferating Cell Nuclear Antigen
Cyclin-dependent kinase inhibitor 1 Chains: I, J, K, L, M, N, O, P
Molecule details ›
Chains: I, J, K, L, M, N, O, P
Length: 22 amino acids
Theoretical weight: 2.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P38936 (Residues: 139-160; Coverage: 13%)
Gene names: CAP20, CDKN1, CDKN1A, CIP1, MDA6, PIC1, SDI1, WAF1

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: R3
Unit cell:
a: 223.693Å b: 223.693Å c: 200.876Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.234 0.261
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.
Strzalka et al. (2011)
4 more

6 mentions without citation

Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.
Strzalka et al. (2009)
5 more