› 2zw3

X-ray diffraction
3.5Å resolution

Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution

Released:
DOI: 10.2210/pdb2zw3/pdb
PDB entry 2zw3 coloured by chain, front view.
PDB entry 2zw3 coloured by chain, side view.
PDB entry 2zw3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the connexin 26 gap junction channel at 3.5 A resolution.
Maeda S, Nakagawa S, Suga M, Yamashita E, Oshima A, Fujiyoshi Y, Tsukihara T
Nature 458 597-602 (2009)
PMID: 19340074

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-2 protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 226 amino acids
Theoretical weight: 26.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29033 (Residues: 1-226; Coverage: 100%)
Gene name: GJB2
Sequence domains: Connexin
Structure domains: Gap junction channel protein cysteine-rich domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2
Unit cell:
a: 167.617Å b: 111.245Å c: 155.387Å
α: 90° β: 114.04° γ: 90°
R-values:
R R work R free
0.338 0.337 0.351
Expression system: Spodoptera frugiperda

Quick links

Citations

111 review citations

Gap junctions.
Goodenough et al. (2009)
110 more

96 mentions without citation

Claudins and the modulation of tight junction permeability.
Günzel et al. (2013)
95 more