› 2zxz

X-ray diffraction
3Å resolution

Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide

Released:
DOI: 10.2210/pdb2zxz/pdb
PDB entry 2zxz coloured by chain, front view.
PDB entry 2zxz coloured by chain, side view.
PDB entry 2zxz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.
Lippert WP, Burschka C, Götz K, Kaupp M, Ivanova D, Gaudon C, Sato Y, Antony P, Rochel N, Moras D, Gronemeyer H, Tacke R
ChemMedChem 4 1143-52 (2009)
PMID: 19496083

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148727 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand P26 1 x P26
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P43212
Unit cell:
a: 64.079Å b: 64.079Å c: 110.389Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.206 0.278
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

5 review citations

SPLINTS: small-molecule protein ligand interface stabilizers.
Fischer et al. (2016)
4 more

3 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
2 more