› 2a4l

X-ray diffraction
2.4Å resolution

Human cyclin-dependent kinase 2 in complex with roscovitine

Released:
DOI: 10.2210/pdb2a4l/pdb
PDB entry 2a4l coloured by chain, front view.
PDB entry 2a4l coloured by chain, side view.
PDB entry 2a4l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH
Eur J Biochem 243 518-26 (1997)
PMID: 9030780

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RRC 1 x RRC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 72.307Å b: 73.069Å c: 54.284Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.173 0.27
Expression system: Spodoptera frugiperda

Quick links

Citations

60 review citations

Protein kinases--the major drug targets of the twenty-first century?
Cohen P. (2002)
59 more

33 mentions without citation

Cyclin-Dependent Kinase 4 and 6 Inhibitors in Cell Cycle Dysregulation for Breast Cancer Treatment.
Susanti et al. (2021)
32 more