› 2a65

X-ray diffraction
1.65Å resolution

Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters

Released:
DOI: 10.2210/pdb2a65/pdb
PDB entry 2a65 coloured by chain, front view.
PDB entry 2a65 coloured by chain, side view.
PDB entry 2a65 coloured by chain, top view.
Source organism: Aquifex aeolicus VF5
Primary publication:
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters.
Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E
Nature 437 215-23 (2005)
PMID: 16041361

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-130575 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+):neurotransmitter symporter (Snf family) Chain: A
Molecule details ›
Chain: A
Length: 519 amino acids
Theoretical weight: 58.08 KDa
Source organism: Aquifex aeolicus VF5
Expression system: Escherichia coli
UniProt:
  • Canonical: O67854 (Residues: 1-513; Coverage: 100%)
Gene names: aq_2077, snf
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

4 bound ligands:
Ligand BOG 5 x BOG
Ligand NA 2 x NA
Ligand CL 1 x CL
Ligand LEU 1 x LEU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2
Unit cell:
a: 87.86Å b: 86.31Å c: 81.02Å
α: 90° β: 95.73° γ: 90°
R-values:
R R work R free
0.199 0.199 0.217
Expression system: Escherichia coli

Quick links

Citations

202 review citations

Biology of human sodium glucose transporters.
Wright et al. (2011)
201 more

196 mentions without citation

Unlocking the molecular secrets of sodium-coupled transporters.
Krishnamurthy et al. (2009)
195 more