› 2a7o

Solution NMR

Solution Structure of the hSet2/HYPB SRI domain

Released:
DOI: 10.2210/pdb2a7o/pdb
PDB entry 2a7o coloured by chain, ensemble of 20 models, front view.
PDB entry 2a7o coloured by chain, ensemble of 20 models, side view.
PDB entry 2a7o coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.
Li M, Phatnani HP, Guan Z, Sage H, Greenleaf AL, Zhou P
Proc Natl Acad Sci U S A 102 17636-41 (2005)
PMID: 16314571

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(36) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(36)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SETD2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BYW2 (Residues: 2457-2564; Coverage: 4%)
Gene names: HIF1, HSPC069, HYPB, KIAA1732, KMT3A, SET2, SETD2
Sequence domains: SRI (Set2 Rpb1 interacting) domain
Structure domains: Set2, Rpb1 interacting domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Reading protein modifications with interaction domains.
Seet et al. (2006)
25 more

15 mentions without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)
14 more