› 2ac3

X-ray diffraction
2.1Å resolution

Structure of human Mnk2 Kinase Domain

Released:
DOI: 10.2210/pdb2ac3/pdb
PDB entry 2ac3 coloured by chain, front view.
PDB entry 2ac3 coloured by chain, side view.
PDB entry 2ac3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Jauch R, Jäkel S, Netter C, Schreiter K, Aicher B, Jäckle H, Wahl MC
Structure 13 1559-68 (2005)
PMID: 16216586

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190755 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-interacting serine/threonine-protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9HBH9 (Residues: 72-385; Coverage: 68%)
Gene names: GPRK7, MKNK2, MNK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P3221
Unit cell:
a: 104.502Å b: 104.502Å c: 72.351Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.215 0.254
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

MAP kinase-interacting kinases--emerging targets against cancer.
Diab et al. (2014)
5 more

12 mentions without citation

Targeting Mnks for cancer therapy.
Hou et al. (2012)
11 more