› 2af0

X-ray diffraction
2.3Å resolution

Structure of the Regulator of G-Protein Signaling Domain of RGS2

Released:
DOI: 10.2210/pdb2af0/pdb
PDB entry 2af0 coloured by chain, front view.
PDB entry 2af0 coloured by chain, side view.
PDB entry 2af0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP
Proc Natl Acad Sci U S A 105 6457-62 (2008)
PMID: 18434541

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 2 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41220 (Residues: 71-203; Coverage: 63%)
Gene names: G0S8, GIG31, RGS2
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 43.754Å b: 43.754Å c: 158.451Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.272 0.226 0.256
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Update on melatonin receptors: IUPHAR Review 20.
Jockers et al. (2016)
21 more

5 mentions without citation

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.
Kimple et al. (2011)
4 more