› 2ahs

X-ray diffraction
2.1Å resolution

Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta

Released:
DOI: 10.2210/pdb2ahs/pdb
PDB entry 2ahs coloured by chain, front view.
PDB entry 2ahs coloured by chain, side view.
PDB entry 2ahs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149972 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 34.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23467 (Residues: 1686-1971; Coverage: 15%)
Gene names: PTPB, PTPRB
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

3 bound ligands:
Ligand CL 9 x CL
Ligand NA 1 x NA
Ligand EDO 8 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6122
Unit cell:
a: 123.368Å b: 123.368Å c: 179.569Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.155 0.152 0.206
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

2 mentions without citation

Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D.
Madan et al. (2011)
1 more