› 2bdw

X-ray diffraction
1.8Å resolution

Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II

Released:
DOI: 10.2210/pdb2bdw/pdb
PDB entry 2bdw coloured by chain, front view.
PDB entry 2bdw coloured by chain, side view.
PDB entry 2bdw coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.
Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J
Cell 123 849-60 (2005)
PMID: 16325579

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II Chains: A, B
Molecule details ›
Chains: A, B
Length: 362 amino acids
Theoretical weight: 40.63 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O62305 (Residues: 1-309; Coverage: 43%)
Gene names: K11E8.1, unc-43
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 46.121Å b: 77.104Å c: 119.52Å
α: 90° β: 96.74° γ: 90°
R-values:
R R work R free
0.216 0.216 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

65 review citations

AMPK in Health and Disease.
Steinberg et al. (2009)
64 more

20 mentions without citation

Ca(2+)/calmodulin-dependent protein kinases.
Swulius et al. (2008)
19 more