› 2bp4

Solution NMR

Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution

Released:
DOI: 10.2210/pdb2bp4/pdb
PDB entry 2bp4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2bp4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2bp4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
Zirah S, Kozin SA, Mazur AK, Blond A, Cheminant M, Ségalas-Milazzo I, Debey P, Rebuffat S
J Biol Chem 281 2151-61 (2006)
PMID: 16301322

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-687; Coverage: 2%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

29 review citations

Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.
Miller et al. (2010)
28 more

6 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
5 more