› 2bxs

X-ray diffraction
3.15Å resolution

Human Monoamine Oxidase A in complex with Clorgyline, Crystal Form B

Released:
DOI: 10.2210/pdb2bxs/pdb
PDB entry 2bxs coloured by chain, front view.
PDB entry 2bxs coloured by chain, side view.
PDB entry 2bxs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B.
De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A
Proc Natl Acad Sci U S A 102 12684-9 (2005)
PMID: 16129825

Function and Biology Details

Reactions catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149227 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amine oxidase [flavin-containing] A Chains: A, B
Molecule details ›
Chains: A, B
Length: 527 amino acids
Theoretical weight: 59.76 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P21397 (Residues: 1-527; Coverage: 100%)
Gene name: MAOA
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
1 bound ligand:
Ligand MLG 2 x MLG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 158.374Å b: 152.076Å c: 82.203Å
α: 90° β: 104.52° γ: 90°
R-values:
R R work R free
0.271 0.268 0.33
Expression system: Komagataella pastoris

Quick links

Citations

43 review citations

The therapeutic potential of monoamine oxidase inhibitors.
Youdim et al. (2006)
42 more

21 mentions without citation

Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.
Ramsay et al. (2016)
20 more