Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Cyclic nucleotide-binding domain
- Ras guanine-nucleotide exchange factors catalytic domain
- Ras-like guanine nucleotide exchange factor, N-terminal
- DEP domain
- Cyclic nucleotide-binding domain superfamily
- RmlC-like jelly roll fold
- Ras guanine-nucleotide exchange factor, conserved site
- Ras guanine-nucleotide exchange factor, catalytic domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Rap guanine nucleotide exchange factor 4 (preferred)
PDBe Complex ID:
PDB-CPX-190168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rap guanine nucleotide exchange factor 4
Molecule details ›
Chain: E
Length: 999 amino acids
Theoretical weight: 114.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 999 amino acids
Theoretical weight: 114.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9EQZ6 (Residues: 1-1011; Coverage: 98%)
Sequence domains:
- Cyclic nucleotide-binding domain
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- RasGEF N-terminal motif
- RasGEF domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID14-4
Spacegroup:
P212121
Expression system: Escherichia coli
